Feather-like Gold Nanostructures Anchored onto 3D Mesoporous Laser-Scribed Graphene: A Highly Sensitive Platform for Enzymeless Glucose Electrochemical Detection in Neutral Media

The authors present a novel sensing platform for disposable electrochemical, non-enzymatic glucose sensor strip at physiological pH. material is based on dendritic gold nanostructures (AuNs) resembling feather branches, which are electrodeposited onto laser-scribed 3D graphene electrode (LSGE). LSGEs were fabricated via one-step laser scribing process commercially available polyimide sheet. This study investigates several parameters that influence the morphology of deposited Au and catalytic activity toward electro-oxidation. electrocatalytic AuNs-LSGE was evaluated using cyclic voltammetry (CV), linear sweep (LSV), amperometry compared to carbon electrodes prepared under same electrodeposition conditions. demonstrated good stability high selectivity amperometric response in presence interfering agents, such as ascorbic acid, when Nafion membrane applied over surface. proposed strategy offers wide detection range, from 0.5 20 mM, covers normal elevated levels blood, with limit 0.21 mM. exhibits great potential use point-of-care applications, including self-monitoring food management. Its features reduce dependence enzymes, making it suitable practical cost-effective biosensing solutions.